| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | Photochromic Ion Channel Blocker, QAQ |
|---|
| Description | Purity ~95% (HPLC). A membrane-impermeant Na+, K+, and Ca2+ channel blocker that is structurally composed of two azo-linked QX-314 type quaternary amines. Both QX-314 and QAQ are shown to selectively target excitability of nociceptor neurons via TRPV1-dependent cellular uptake. Unlike QX-314, the channel blocking activity of QAQ can be quickly switched on and off via optical cis-to-trans (500nM) and trans-to-cis (320nM) isomerization. Its efficacy as a pain-selective, photochromic anesthetic has been demonstrated in rats in vivo. QAQ cellular uptake can also be achieved by ATP-activated P2X7 receptor. Solubility: DMSO Primary Target: Ion Channels Molar Mass: 586.72 |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Photochromic Ion Channel Blocker, QAQ (2,2'-((diazene-1,2-diylbis(4,1-phenylene))bis(azanediyl))bis(N,N,N-triethyl-2-oxoethanaminium) formate, Quaternary Ammonium-Azobenzene-Quaternary Ammonium) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217654 |
|---|
| Price | |
|---|
| Order / More Info | Photochromic Ion Channel Blocker, QAQ from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|