| 產(chǎn)品詳情 |
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| Antigenic Specificity | Mouse P2X7R |
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| Clone | 1F11 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, κ |
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| Format | TotalSeq?-A oligomer conjugate |
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| Size | 10 μg |
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| Concentration | n/a |
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| Applications | PG |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TotalSeq?-A0824 anti-mouse P2X7R. P2X7R, also known as P2X7 receptor, belongs to the family of ligand-gated ion channel receptors. It is expressed on T cells, B cells, macrophages, and microglia. The receptor opens in the presence of extracellular ATP or NAD, leading to intracellular calcium mobilization. P2X7R activation requires higher concentrations of ATP compared to other P2X receptors. Longer stimulation results in larger pores, allowing passage of larger molecules. Activation of these molecules also leads to mitochondrial and cytoskeletal changes as well as IL-1β maturation and release. Ligation of P2X7 receptor can lead to membrane blebbing and cell death. |
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| Immunogen | Murine colon mast cells |
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| Other Names | P2X7 receptor (P2X7R), P2RX7 |
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| Gene, Accession # | Gene ID: 18439 |
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| Catalog # | 148711 |
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| Price | |
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| Order / More Info | Mouse P2X7R Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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