| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | B7-H4 |
|---|
| Clone | HMH4-5G1 |
|---|
| Host Species | Armenian Hamster |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG |
|---|
| Format | allophycocyanin (APC) conjugate |
|---|
| Size | 100 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | APC anti-mouse B7-H4 (B7S1, B7X). B7-H4 is a newly discovered B7 family member that negatively regulates T cell immunity. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockage of endogenous B7-H4 by specific monoclonal antibodies promotes T cell responses. A new reported function of B7-H4 is as an important negative regulator of innate immunity through growth inhibition of neutrophils. It has been reported that B7-H4 is not constitutively expressed on peripheral tissues but can be induced to express on T cells, B cells, macrophages, and dendritic cells. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. Although B- and T-lymphocyte attenuator (BTLA) was proposed to be the receptor for B7-H4, further studies are needed to identify the inhibitory receptor of B7-H4. |
|---|
| Immunogen | Mouse B7-H4 human IgG1 Fc fusion protein |
|---|
| Other Names | B7H4, B7S1, B7-S1, B7x |
|---|
| Gene, Accession # | Gene ID: 242122 |
|---|
| Catalog # | 139408 |
|---|
| Price | |
|---|
| Order / More Info | B7-H4 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|