| 產(chǎn)品詳情 |
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| Antigenic Specificity | Lamin A |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 200 μl |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Lamin A. Lamin A is a member of the intermediate filament family that contains a farnesyl binding domain and forms dimers. Three isoforms of Lamin A have been reported designated A, AD10, C, with molecular weights of approximately 70 kD, 66 kD, and 61 kD, respectively. Lamin A is localized to the nucleoplasmic side of inner nuclear membrane. Lamin A is thought to function as a fibrous component of the nuclear lamina, providing a framework for the nuclear envelope, and possibly interacting with chromatin. Expression of lamin A is strictly under cell cycle control as seen by disintegration/formation of nuclear envelope in prophase/telophase. Lamin A is modified by phosphorylation, methylation, and farnesylation; phosphorylation regulates disassembly. Lamin A forms a homodimer with Lamin C and has also been shown to interact with the LAPs 1A-1C, emerin, Narf, hsMOK2, PKC, SREBP1a, and SREBP 1c. The Poly6135 antibody recognizes the C-terminal region of human and mouse Lamin A and has been shown to be useful for Western blotting and immunofluorescence staining. |
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| Immunogen | Recombinant (partial), C-terminal |
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| Other Names | LMNA |
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| Gene, Accession # | Gene ID: 4000 |
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| Catalog # | 613502 |
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| Price | |
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| Order / More Info | Lamin A Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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