| 產(chǎn)品詳情 |
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| Product Name | Recombinant Human NADPH oxidase 4 (NOX4), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 28.8kDa. Partial: 210-424aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD (P)H-oxidase; RENOX |
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| Gene, Accession, CAS # | NOX4, UniProt: Q9NPH5 |
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| Catalog # | RPC25645 |
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| Order / More Info | Recombinant Human NADPH oxidase 4 (NOX4), partial from BIOMATIK |
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| Product Specific References | n/a |
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