| 產(chǎn)品詳情 |
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| Product Name | LMIR5, Fc Chimera, Recombinant, Mouse |
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| Description | Purity ~90% (SDS-PAGE). LMIR5, also known as CD300LB, CLM-7, and IREM-3, is a 26kD-32kD glycoprotein member of the immunoglobulin superfamily. Mouse LMIR5 consists of a 140aa extracellular domain (ECD) with one Ig-like V-type domain, a 21aa transmembrane segment, and a 31aa cytoplasmic domain. Within the ECD, mouse LMIR5 shares 51% and 86% aa sequence identity with human and rat LMIR5, respectively. The transmembrane segment contains a positively charged lysine which enables the association of LMIR5 with DAP12, DAP10, and potentially other adaptor proteins. The cytoplasmic domain of human LMIR5 contains a phosphorylatable tyrosine motif, while that of mouse LMIR5 does not. LMIR5 is expressed on the surface of myeloid lineage cells. It forms noncovalent cis-homodimers and cis-heterodimers with other CD300 family proteins, and the composition of these dimers affects the cellular response. Antibody cross-linking of LMIR5 induces mast cell granule release and cytokine production as well as |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LMIR5, Fc Chimera, Recombinant, Mouse (CD300LB, CMRF35-like Molecule 7, CLM-7, CD300 Antigen-like Family Member B, Immune Receptor Expressed on Myeloid Cells 3, IREM-3, Leukocyte Mono-Ig-like Receptor 5, Cd300lb, Irem3) |
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| Gene, Accession, CAS # | SwissProt: Q3U497 |
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| Catalog # | L3189-85 |
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| Order / More Info | LMIR5, Fc Chimera, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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