| 產(chǎn)品詳情 |
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| Antigenic Specificity | ITK |
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| Clone | W15110A |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Intracellular Staining for Flow Cytometry (ICFC), ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-ITK. IL2-inducible T-cell kinase (ITK) is an intracellular tyrosine kinase that is expressed in T cells. It regulates the proliferation, differentiation and development of conventional T cells and NK T cells. This protein has 620 amino acids and contains one PH domain for cell membrane recruitment, one protein kinase domain, and both SH2 and SH3 domains which are commonly found in intracellular kinases. Once T cells are activated, a series of phosphorylation recruits and activates ITK through autophosphorylation. The activated ITK can activate downstream intracellular calcium mobilization and NFAT nucleus translocation, and in turn, activate T cells. The phenotypes of mice deficient in ITK show severely affected immune response and development. |
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| Immunogen | Partial human ITK recombinant protein (1-200 a.a.) expressed in E. coli. |
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| Other Names | Interleukin-2-inducible T-cell kinase, T-cell-specific kinase, EMT, LYK, PSCTK2 |
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| Gene, Accession # | Gene ID: 3702 |
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| Catalog # | 687302 |
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| Price | |
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| Order / More Info | ITK Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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