| 產(chǎn)品詳情 |
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| Product Name | XL413 (hydrochloride) |
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| Description | A potent inhibitor of Cdc7 (IC50 = 3.4 nM); >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively; inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively); inhibits Cdc7-specific phosphorylation of MCM2 and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells; inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model at 10, 30, and 100 mg/kg |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1169558-38-6 1169562-71-3 XL-413 CDC-7 CK-2 PIM-1 MDAMB231T MDAMB-231T 231-T COLO205 MCM |
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| Gene, Accession, CAS # | CAS: 2062200-97-7 |
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| Catalog # | 24906-50 |
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| Price | |
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| Order / More Info | XL413 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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