| 產(chǎn)品詳情 |
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| Product Name | DCPIB |
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| Description | Volume-sensitive anion channel (VSAC) blocker (IC50 ~ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro. Purity 98%. MW (observed): 427.37 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid |
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| Gene, Accession, CAS # | CAS: 82749-70-0 |
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| Catalog # | 1540/10 |
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| Order / More Info | DCPIB from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 18206872, 18923056, 20008476, 21150294, 21381023, 21517854, 23371009, 23383255, 25097230, 25646474, 26552848 |
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