| 產(chǎn)品詳情 |
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| Antigenic Specificity | LCK Phospho (Tyr505) |
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| Clone | A17013B |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-LCK Phospho (Tyr505). The Src family tyrosine kinase p56Lck (LCK) is a non-receptor tyrosine kinase that plays a critical role in T cell selection and maturation within the thymus, and also in the function of mature T cells. LCK, which is constitutively bound to cytosolic domains of CD4 and CD8 surface receptors, plays an essential role in T cell receptor (TCR) signaling. Engagement of the TCR with peptide antigen-loaded MHC complex results in the recruitment of CD4- and CD8-bound LCK to the TCR/CD3 signaling complex. LCK then transphosphorylates TCR-gamma chains and CD3 subunits, thereby activating the TCR/CD3 signaling pathway and leading to the recruitment and subsequent phosphorylation of Zap70 by LCK. LCK also plays an important role in interleukin-2 signaling that regulates the T cell proliferative response. Phosphorylation of LCK by CSK at Tyrosine 505 negatively regulates LCK, and is proposed to generate a closed, inactive conformation of the protein. |
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| Immunogen | Human LCK peptide phosphorylated at Tyr 505. |
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| Other Names | Leukocyte C-terminal Src kinase, Protein YT16, p56-LCK, T cell-specific protein-tyrosine kinase |
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| Gene, Accession # | Gene ID: 3932 |
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| Catalog # | 684302 |
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| Price | |
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| Order / More Info | LCK Phospho (Tyr505) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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