| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | iLite? IL-12 Assay Ready Cells |
|---|
| Description | Interleukin 12 (IL-12) is a 70 kDa cytokine produced principally by macrophages, neutrophils and dendritic cells in response to stimulation by antigen. IL-12 is a T cell-stimulating factor, playing a critical role in the regulation of T-helper 1 cell responses. IL-12 is composed of two subunits, p35 and p40, covalently linked by a single disulfide bond. The p40 subunit, which binds to the receptor chain IL-12Rβ1, is shared with another heterodimeric cytokine, IL-23. However, the two cytokines expert distinct non-redundant biological functions (1). Therapeutic agents targeting both IL-12 and IL-23 cytokines are currently used to treat psoriasis and psoriatic arthritis, and related agents are in clinical testing for a variety of inflammatory disorders (2). iLite? IL-12 Assay Ready Cells are a genetically engineered reporter gene cell line (DT-40, ATCC#CRL-2111) responsive to Interleukin-12 by specific and proportional expression of Firefly Luciferase. Normalization of cell counts and serum matrix effects is obtained by a second reporter gene, a Renilla Luciferase reporter gene construct, under the control of a constitutive promotor. |
|---|
| Size | 250 ul |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | BM4012 |
|---|
| Price | |
|---|
| Order / More Info | iLite® IL-12 Assay Ready Cells from EAGLE BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|