| 產(chǎn)品詳情 |
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| Product Name | CI-976 |
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| Description | Purity >95%. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O -acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide, PD 128042 |
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| Gene, Accession, CAS # | CAS: 114289-47-3 |
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| Catalog # | LS-H7135 |
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| Order / More Info | CI-976 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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