| 產品詳情 |
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| Product Name | Rosiglitazone (potassium salt) |
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| Description | A thazolidinedione agonist of PPARγ; binds to the LBD of PPARγ (Kd = 43 nM); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 μM; activates full-length PPARγ1 and PPARγ2 in a reporter assay (EC50s = 30 and 100 nM, respectively); induces differentiation of C3H10T1/2 stem cells to adipocytes at 1 μM; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate/high-fat diet at 4 mg/kg; inhibits increases in contusion volume, macrophage infiltration and activation of microglia, and expression of IL-6, MCP1, ICAM1, caspase-3, and Bax in mouse cerebral cortex in a model of traumatic brain injury induced by controlled cortical impact at 6 mg/kg |
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| Size | 100 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BRL49653 BRL-49653 PPAR-γ α δ γ1 γ2 Hb-A1c IL6 MCP-1 ICAM-1 |
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| Gene, Accession, CAS # | CAS: 316371-84-3 |
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| Catalog # | 71742-100 |
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| Price | |
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| Order / More Info | Rosiglitazone (potassium salt) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產品資料 |
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