| 產(chǎn)品詳情 |
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| Antigenic Specificity | BCAR3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BCAR3 Antibody detects endogenous levels of BCAR3. A ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described. |
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| Immunogen | n/a |
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| Other Names | BCAR3; NSP2; SH2D3B; breast cancer anti-estrogen resistance 3; KIAA0554; OTTHUMP00000011961; breast cancer antiestrogen resistance 3; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B; SH2-containing protein Nsp2 |
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| Gene, Accession # | BCAR3, Gene ID: 8412, SwissProt: O75815 |
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| Catalog # | abx010337 |
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| Price | |
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| Order / More Info | BCAR3 Antibody from ABBEXA |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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