| 產(chǎn)品詳情 |
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| Antigenic Specificity | BACE1 |
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| Clone | 3C1C3 |
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| Host Species | Mouse |
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| Reactive Species | canine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 1:50-1:200, Western Blot: 1:1000-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BACE1 Monoclonal Antibody (3C1C3). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. |
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| Immunogen | n/a |
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| Other Names | BACE, ASP2, HSPC104, C76936 |
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| Gene, Accession # | Entrez: 23621, 23821, 29392, 489390; Uniprot: P56817, P56818, P56819 |
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| Catalog # | MA1-177 |
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| Price | |
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| Order / More Info | BACE1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 29176823 |
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| 產(chǎn)品資料 |
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