| 產(chǎn)品詳情 |
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| Antigenic Specificity | BACE |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | ion exchange purified |
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| Size | 100 μg |
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| Concentration | 1 mg/ml |
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| Applications | Western blot, Immunohistochemistry, ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BACE Antibody (CT). Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleav |
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| Immunogen | A peptide corresponding to 17 amino acids at the CT of human BACE. |
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| Other Names | BACE (CT). Asp2 |
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| Gene, Accession # | Gene ID: 23621, Accession: P56817 |
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| Catalog # | 5051-100 |
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| Price | |
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| Order / More Info | BACE Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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