| 產(chǎn)品詳情 |
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| Antigenic Specificity | BACE1 (CO2 terminus) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Anti-BACE1 (CO2 terminus). Beta-secretase 1 (BACE1) is a novel membrane bound aspartyl protease that cleaves the β-amyloid precursor protein (βAPP) to generate the N-terminus of the Aβ domain. The membrane bound C-terminal fragment generated by the beta secretase cut is subsequently cleaved by the gamma secretase, resulting in the generation and secretion of the Aβ. The amyloidogenic peptide Aβ is a major factor in the etiology of Alzheimer’s disease. |
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| Immunogen | B690 was raised against a peptide sequence CLRQQHDDFADDISLLK , the C-terminal 17 amino acids of the human BACE1 and recognizes the mature and immature forms of BACE. |
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| Other Names | Beta-Secretase 1, Asp 2, Memapsin-2, App Beta-Secretase, Aspartyl Protease 2, Beta-Site App Cleaving Enzyme 1, Beta-Secretase 1 Precursor Variant 1, Transmembrane Aspartic Proteinase Asp2, Membrane-Associated Aspartic Protease 2, Beta-Site Amyloid Beta A4, B690, PRB-617C-100 |
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| Gene, Accession # | Gene ID: 23621 |
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| Catalog # | 840101 |
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| Price | |
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| Order / More Info | BACE1 (CO2 terminus) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 25474204 |
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| 產(chǎn)品資料 |
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