| 產(chǎn)品詳情 |
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| Antigenic Specificity | Human CD49d |
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| Clone | 9F10 |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, cat (feline), cattle (bovine, cow), chimpanzee, common marmoset, cynomolgus, dog (canine), horse (equine), rhesus, sheep (ovine), squirrel monkey |
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| Isotype | IgG1, κ |
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| Format | Brilliant Violet 785? conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Brilliant Violet 785? anti-human CD49d. CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
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| Immunogen | n/a |
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| Other Names | VLA-4 α chain, α4 integrin, Integrin α4 chain, ITGA4 |
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| Gene, Accession # | Gene ID: 3676 |
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| Catalog # | 304343 |
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| Price | |
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| Order / More Info | Human CD49d Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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