| 產(chǎn)品詳情 |
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| Antigenic Specificity | Amphiregulin |
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| Clone | 1501107 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Amphiregulin. Amphiregulin was initially identified in the conditioned medium of human mammary gland MCF-7 cells treated with TPA. The mouse gene was cloned from the androgen-dependent SC2G cell line derived from Shionogi mouse mammary carcinoma SC115. It belongs to the EGF family of proteins that includes EGF, TGF-α, heparin-binding EGF like-growth factor (HB-EGF), epigen, epiregulin, and betacellulin. Mouse amphiregulin is derived from a 248 amino acid transmembrane precursor and it has 66% identity to the human protein. All the EGF family members are synthesized as type I membrane protein precursors, which can undergo proteolytic cleavage at the plasma membrane to release a mature soluble ectodomain. ADAM17 (TACE) has an important role in ectodomain shedding of amphiregulin, TNF-α, and HB-EGF. This cleavage is a key step in the control of ligand availability and receptor activation. It is stimulated by physiological and pharmacological agonists, including TPA, calcium ionophores, GPCR ligands, cytokines, and growth factors. Amphiregulin is a paracrine regulator of estrogen action during ductal morphogenesis (mammary gland development), and it has been associated with breast cancer initiation and progression. Amphiregulin is elevated in psoriatic lesional skin, gastrointestinal carcinomas, colorectal cancer, and hepatocelular carcinoma tissues. In addition, FOXP3+ Tregs express EGFR under inflammatory conditions, and amphiregulin enhances regulatory T cell-suppressive function in vitro and in vivo in a colitis and tumor vaccination model. |
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| Immunogen | Purified mouse Amphiregulin, amino acids (Ser94-Lys191) (Accession# NM_009704) expressed in E. coli. |
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| Other Names | Amphiregulin (AR), AREG, Schwannoma-derived growth factor (SDGF), Colorectum cell-derived growth factor (CRDGF) |
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| Gene, Accession # | Gene ID: 11839 |
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| Catalog # | 684802 |
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| Price | |
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| Order / More Info | Amphiregulin Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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