| 產(chǎn)品詳情 |
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| Antigenic Specificity | O-GlcNAc |
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| Clone | RL2 |
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| Host Species | Mouse |
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| Reactive Species | n/a |
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| Isotype | IgG1, λ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF), IHC, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-O-GlcNAc. The monoclonal antibody RL2 reacts specifically with beta-O-linked N-acetylglucosamine (O-GlcNAc). It recognizes o-GlcNAc in beta O-glycosidic linkage to both serine and threonine. However, it exhibits no cross reactivity with alpha-linked Ser-O-linked N-acetylgalactosamine or N-linked oligosaccharides on ovalbumin and immunoglobulin. This antibody readily detects in vivo changes in O-GlcNAc modification1.O-GlcNAc is one of the most abundant posttranslational modifications within the nucleocytoplasmic compartments of all metazoans2. O-GlcNAcylation is similar to protein phosphorylation. Research on O-GlcNAc is particularly relevant to chronic human diseases such as diabetes, cardiovascualr disease, neurodegenerative disorders, and cancer3.Like phosphorylation, the specific functions of O-GlcNAc depend on the protein and sites to which the glycan is attached2. One of the major functions of O-GlcNAc is to prevent O-phosphorylation and to modulate signaling and transcription in response to cellular nutrients or stress4. |
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| Immunogen | O-GlcNAc in beta-O-glycosidic linkage to both serine and threonine. |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | 677902 |
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| Price | |
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| Order / More Info | O-GlcNAc Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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