| 產(chǎn)品詳情 |
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| Antigenic Specificity | Toll-Like Receptor 7 (TLR7) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TLR7, 8 and 9 form a group of structurally related TLR family members that are are localized to intracellular endosomes. TLR7 shows highest expression in lung, placenta, and spleen. TLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responses. Naturally, TLR7 responds to ssRNA viruses to activate NF-kappaB and trigger IFN production.Synonyms: TLR7 |
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| Immunogen | Recombinant protein of human TLR7 |
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| Other Names | TLR7A|TLR7-like|RGD1563357 |
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| Gene, Accession # | Gene ID: 51284,170743,317468 |
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| Catalog # | ABIN1514758 |
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| Price | |
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| Order / More Info | Toll-Like Receptor 7 (TLR7) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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