| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | CD41/CD61 |
|---|
| Clone | A2A9/6 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a, κ |
|---|
| Format | purified, azide-free |
|---|
| Size | 500 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC), Block, IP |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Ultra-LEAF? Purified anti-human CD41/CD61. CD41/CD61, also known as gpIIb/IIIa, is a member of a family integrin receptors. This is a complex comprised by CD41 and CD61 through non-covalent association. CD41/CD61 is mainly expressed by platelets and megakaryocytes. The resting form of the CD41/CD61 complex is involved in platelet activation and aggregation by binding to immobilized fibrinogen. After activation, CD41/CD61 becomes a receptor for soluble fibrinogen and several other RGD-containing adhesive proteins such as von Willebrand Factor (vWF) and fibronectin. An absence or dysfunction of CD41/CD61 on the platelet surface results in an inherited bleeding disorder, called Glanzmann Thromsasthenia (GT). CD41/CD61 has been found on murine hematopoietic progenitor cells, indicating that this complex may play a role in regulating hematopoietic development. |
|---|
| Immunogen | Human platelets |
|---|
| Other Names | gpIIb/gpIIIa |
|---|
| Gene, Accession # | Gene ID: 3674, 3690 |
|---|
| Catalog # | 359804 |
|---|
| Price | |
|---|
| Order / More Info | CD41/CD61 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|