| 產(chǎn)品詳情 |
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| Product Name | SF2523 |
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| Description | A dual inhibitor of PI3K and BRD4 (IC50s = 16, and 241 and 1,550 nM for PI3K, and BRD4 bromodomains 1 and 2, respectively); reduces MYCN gene expression and decreases MYCN and cyclin D1 protein levels; inhibits phosphorylation of Akt in SKNBE2 cells; reduces tumor volume and protein levels of MYCN and cyclin D1 in a MYCN-amplified SKNBE2 neuroblastoma xenograft model in mice; reduces tumor growth and the number of colonic lymph node metastases in the murine orthotopic pancreatic Panc02 carcinoma model |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SF-2523 BRD-4 2 1 Panc-02 SKNBE-2 BRD1 BRD2 |
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| Gene, Accession, CAS # | CAS: 1174428-47-7 |
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| Catalog # | 21638-1 |
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| Price | |
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| Order / More Info | SF2523 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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