| 產(chǎn)品詳情 |
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| Product Name | Dorsomorphin dihydrochloride |
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| Description | Potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and metformin (Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. Purity 98%. MW (observed): 472.41 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride. Compound C, BML-275 |
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| Gene, Accession, CAS # | CAS: 1219168-18-9 |
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| Catalog # | 3093/10 |
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| Order / More Info | Dorsomorphin dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 20548307, 21715426, 21896918, 21958075, 21982708, 22306606, 22968320, 22972918, 23076030, 23154389, 23362023, 23507034, 23533608, 23555697, 23563587, 23616923, 23754277, 24216509, 24291815, 24308972, 24497921, 25080434, 25286122, 25514175, 25605781, 25622260, 25654758, 25693565, 25822089, 26029847, 26136155, 26136928, 26174015, 26272509, 26539519, 26541394, 26801615, 27320041, 27378374, 27396242, 27428650, 28039410, 28613987, 29396410 |
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