| 產(chǎn)品詳情 |
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| Product Name | Ruxolitinib (phosphate) |
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| Description | A potent ATP mimetic that inhibits JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; less selective for JAK3 (IC50 = 322 nM); blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN, |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | INC 424 (phosphate)|INCB 018424 (phosphate) |
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| Gene, Accession, CAS # | CAS: 1092939-17-7 |
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| Catalog # | 23215-25 |
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| Price | |
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| Order / More Info | Ruxolitinib (phosphate) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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