| 產(chǎn)品詳情 |
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| Antigenic Specificity | PTRH2/BIT1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PTRH2/BIT1 Polyclonal Antibody. Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES compl |
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| Immunogen | n/a |
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| Other Names | OTTHUMP00000205936; PTH 2; bcl-2 inhibitor of transcription 1; peptidyl-tRNA hydrolase 2, mitochondrial |
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| Gene, Accession # | Entrez: 51651; Uniprot: Q9Y3E5 |
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| Catalog # | A305-224A-M |
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| Price | |
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| Order / More Info | PTRH2/BIT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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