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| Antigenic Specificity | PTPN7 |
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| Clone | AFPK32 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Western Blot: 1:5000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PTPN7 Monoclonal Antibody (AFPK32). Hematopoietic tyrosine phosphatase (HePTP, PTPN7) belongs to a subgroup of PTPases with two other members, STEP and PCPTP1. HePTP is a 38 kDa class I non-receptor protein tyrosine phosphatase (PTP) that is strongly expressed in T cells. The protein consists of a short, amino-terminal extension that contains a conserved 16-amino acid kinase interaction motif (KIM) and a carboxy-terminal protein tyrosine phosphatase domain. HePTP binds the MAPK family kinases, Erk1/2 and p38 via KIM. Erk phosphorylates HePTP (at Thr45 and Ser72) and HePTP dephosphorylates Erk (at Tyr185). HePTP is phosphorylated at Ser23 within the KIM by PKA in T cells. This phosphorylation results in dissociation of the HePTP/ERK2 complex |
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| Immunogen | n/a |
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| Other Names | Tyrosine-protein phosphatase non-receptor type 7; Protein-tyrosine phosphatase LC-PTP; Hematopoietic protein-tyrosine phosphatase; LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP |
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| Gene, Accession # | Entrez: 5778; Uniprot: P35236 |
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| Catalog # | MA5-17227 |
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| Price | |
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| Order / More Info | PTPN7 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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