| 產(chǎn)品詳情 |
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| Antigenic Specificity | S100A7, Human |
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| Clone | 9F3 |
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| Host Species | Mouse |
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| Reactive Species | human, dog, rabbit, rat, sheep |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | 100 μg/ml |
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| Applications | functional studies, immunoassay, IF, paraffin sections, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Does not react with: mouse. Antibody 9F3 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7 interacts with RAGE which drives an NF-κB mediated proinflammatory response and recruitment of neutrophils. S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to, and reduces survival of, pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior. |
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| Immunogen | Full length recombinant human S100A7 |
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| Other Names | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7. |
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| Gene, Accession # | S100A7, PSOR1, S100A7C |
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| Catalog # | HM2328 |
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| Price | |
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| Order / More Info | S100A7, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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