| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Spi-6, Mouse |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | FC, immunoassay, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6. |
|---|
| Immunogen | Recombinant GST-Spi-6 |
|---|
| Other Names | Cytoplasmic antiproteinase 3, serpin B9, PI-9 |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HP8035 |
|---|
| Price | |
|---|
| Order / More Info | Spi-6, Mouse Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|