| 產(chǎn)品詳情 |
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| Antigenic Specificity | SP-B, Pig |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | pig, human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | 100 μg/ml |
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| Applications | immunoassay, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The polyclonal antibody recognizes the human surfactant protein B (SP-B). There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-B is synthesized by the alveolar type II epithelial cells as a 40-42 kD precursor that is subsequently proteolytically processed to 7.8-8 kD. SP-B enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-B is essential for air-breathing in mammals and is therefore largely conserved. SP-B can interact with both phospholipid head groups and fatty chains and is particularly active in enhancing surface active behaviour in endogenous and exogenous lung surfactants. Even low SP-B contents had measurable effects in increasing the adsorption, dynamic surface tension lowering, and/or film respreading of DPPC, mixed synthetic lipids, and column-purified lung surfactant phospholipids. Deficiency of SP-B and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). The polyclonal antibody is raised against pig SP-B from pig lungs which has been reconstituted in micelles of lysophosphatidylcholine. The antibody rescognizes under nonreducing conditions the most prominent forms of SP-B of 8 kD and 22 kD, corresponding to SP-B dimers. The polyclonal antibody is cross reactive with human SP-B. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | HP7002 |
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| Price | |
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| Order / More Info | SP-B, Pig Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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