| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | STIMA-1 |
|---|
| Description | STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax. MW: 172.19. Purity ≥97% |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis |
|---|
| Gene, Accession, CAS # | CAS: 91634-12-7 |
|---|
| Catalog # | 9437-10 |
|---|
| Price | |
|---|
| Order / More Info | STIMA-1 from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|