| 產(chǎn)品詳情 |
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| Antigenic Specificity | IL-21 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IL-21 Polyclonal Antibody. IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulatio |
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| Immunogen | n/a |
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| Other Names | IL-21, Za11 |
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| Gene, Accession # | Entrez: 59067; Uniprot: Q9HBE4 |
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| Catalog # | PA5-34801 |
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| Price | |
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| Order / More Info | IL-21 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 28108473 |
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| 產(chǎn)品資料 |
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