| 產(chǎn)品詳情 |
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| Antigenic Specificity | GAD65/GAD67 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GAD65/GAD67 Polyclonal Antibody. GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms ex |
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| Immunogen | n/a |
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| Other Names | Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD 65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD-65, GAD 2, GAD-2, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD 67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67, GAD-1, GAD 1 |
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| Gene, Accession # | Entrez: 14415, 14417, 24379, 24380, 2571, 2572; Uniprot: P18088, P48318, P48320, Q05329, Q05683, Q99259 |
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| Catalog # | PA5-36080 |
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| Price | |
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| Order / More Info | GAD65/GAD67 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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