| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | IRS-1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 100 μg |
|---|
| Concentration | 0.5 mg/ml |
|---|
| Applications | Western blot, Immunohistochemistry |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | IRS-1 Antibody. IRS-1 (Insulin receptor substrate-1) is phosphorylated in response to stimulation of cells by insulin. Upon ligand-induced phosphorylation, IRS-1 immediately associates with a series of SH2 domain-containing signaling intermediates such as PI3-kinase, GRB2, Syp and Nck. The level of diversity in structure and function of the SH2-containing proteins which binds activated IRS-1 is important for responsiveness to insulin. IRS phosphorylation elicits the growth and metablic effects of insulin growth factors and insulin by allowing glucose uptake, glycogen synthesis and mitogenic activity. IRS-1 migrates between 170 and 185 kDa and is expressed in most cell types. |
|---|
| Immunogen | Synthetic peptide mapping to the C-terminus of human IRS-1 |
|---|
| Other Names | IRS1 , HIRS-1 |
|---|
| Gene, Accession # | Gene ID: 3667, Accession: P35568 |
|---|
| Catalog # | 3424-100 |
|---|
| Price | |
|---|
| Order / More Info | IRS-1 Antibody from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|