| 產(chǎn)品詳情 |
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| Product Name | BAFF-R,Fc, Recombinant, Human |
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| Description | Purity >95% (SDS-PAGE). BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjogren's syndrome , Rheumatoid Arthritis (RA) , Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF is |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BAFF-R,Fc, Recombinant, Human (TNFRSF 13C, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BlySR3, CD268, BAFF Receptor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44588 |
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| Price | |
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| Order / More Info | BAFF-R,Fc, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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