| 產(chǎn)品詳情 |
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| Antigenic Specificity | CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) (aa 210-260) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Tissue specificity: Testis specific. Specifically expressed in primary spermatocytes.Synonyms: Transcriptional repressor CTCFL, Brother of the regulator of imprinted sites, CCCTC-binding factor, CTCF paralog, CTCF-like protein, Cancer/testis antigen 27, CT27, Zinc finger protein CTCF-T, CTCFL |
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| Immunogen | A synthetic peptide from aa region 210-260 of human BORIS conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | CTCFL|BORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2|Boris|OTTMUSG00000016680 |
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| Gene, Accession # | Gene ID: 140690 |
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| Catalog # | ABIN1842104 |
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| Price | |
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| Order / More Info | CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) (aa 210-260) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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