| 產(chǎn)品詳情 |
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| Antigenic Specificity | Ficolin-1, Human |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 50 μg |
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| Concentration | 50 μg/ml |
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| Applications | FC, IF, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The polyconal antibody recognizes human Ficolin-1, also known as M-ficolin and ficolin/P35-related protein. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. However, it was recently also found in serum suggesting that Ficolin-1 also has a role in systemic immunity like Ficolin-2 and Ficolin-3. Functional analysis of Ficolin-1 has demonstrated that it's ligand is sialic acid present on bacteria since binding was abolished by prior treatment of the bacteria with sialidase. Furthermore, it was shown that Ficolin-1 facilitates the uptake of E. coli by a leukemic monocyte lymphoma cell line, suggesting that it functions as a phagocytic receptor on the surface of circulating monocytes. Low cord blood concentration of Ficolin-1 has been associated with higher necrotizing enterocolitis-associated fatality and two identified SNPs in the Ficolin-1 gene are associated with the development of rheumatoid arthritis. Ficolin-1 has 75.3% amino acid identity with Ficolin-2 and 47.8% identity with Ficolin-3. Its mRNA is present in leukocytes and lung. Like its family members Ficolin-2 and Ficolin-3, Ficolin-1 is associated with MASPs and sMAP and activates the lectin pathway. The antibody to human Ficolin-1 is cross reactive with human Ficolin-2. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | HP9039 |
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| Price | |
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| Order / More Info | Ficolin-1, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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