| 產(chǎn)品詳情 |
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| Antigenic Specificity | PSAP |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 μl, 100 μl, 200 μl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IHC, IF/ICC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PSAP Antibody is a Rabbit Polyclonal antibody against PSAP. The PSAP gene encodes prosaposin, a precursor of four small nonenzymatic glycoproteins termed 'sphingolipid activator proteins' (SAPs) that assist in the lysosomal hydrolysis of sphingolipids. After proteolytic processing of the presaposin protein, these 4 released polypeptides are functional activators. Saposin A is encoded by residues 60 to 143 of PSAP, saposin B by 195 to 275, saposin C by 311 to 390, and saposin D by 405 to 487. They are four 12-14 kDa heatstable glycoproteins. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. Saposins A-D are required for the hydrolysis of certain sphingolipids by specific lysosomal hydrolases. (PMID: 2001789) Defects in PSAP are the cause of Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy (PubMed: 2060627, PMID: 15773042). This PSAP antibody (10801-1-AP) is expected to recognize both saposin A and B. |
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| Immunogen | Recombinant protein of human PSAP. |
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| Other Names | flj00245; glba; mgc110993; prosaposin; prosaposin (variant gaucher disease and variant metachromatic leukodystrophy); prosaposin (variant gaucher disease and variant metachromatic leukodystrophy) variant; prosaposin isoform a preproprotein; prosaposin iso; SAP1; PSAP |
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| Gene, Accession # | PSAP, Gene ID: 5660, SwissProt: P07602 |
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| Catalog # | abx001503 |
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| Price | |
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| Order / More Info | PSAP Antibody from ABBEXA |
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| Product Specific References | n/a |
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