| 產(chǎn)品詳情 |
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| Antigenic Specificity | VAP-1, Human |
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| Clone | 174-5 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | 100 μg/ml |
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| Applications | frozen sections, FC, functional studies, IF |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 174-5 recognises human Vascular Adhesion Protein-1 (VAP-1), which- is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains- a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part.- A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP-1serum- levels have been described in several inflammatory- diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic- target for modulating inflammation.The monoclonal antibody 174-5 has been shown to cross-react with rat VAP-1 and to inhibit lymphocyte infiltration in rat liver allograft rejection. |
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| Immunogen | Purified vessels from human peripheral lymph nodes (ref 1) |
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| Other Names | membrane primary amine oxidase; AOC3; SSAO |
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| Gene, Accession # | n/a |
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| Catalog # | HM2213 |
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| Price | |
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| Order / More Info | VAP-1, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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