| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | TNF-alpha, Human |
|---|
| Clone | 52B83 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, guinea pig, mouse, rhesus monkey |
|---|
| Isotype | IgG1 |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | frozen sections, FC, immunoassay, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Tumor Necrosis Factor-alpha, TNF, TNF-SF2, cachectin |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM2010 |
|---|
| Price | |
|---|
| Order / More Info | TNF-alpha, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|