| 產(chǎn)品詳情 |
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| Antigenic Specificity | Human TRAF6 |
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| Clone | 2I5M3 |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, nonhuman primate |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human TRAF6 monoclonal antibody for WB. Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac. |
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| Immunogen | Protein corresponding to Human TRAF6 (aa 251-522) |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 7189, UniProt: Q9Y4K3 |
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| Catalog # | CABT-L1647 |
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| Price | |
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| Order / More Info | Human TRAF6 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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