| 產(chǎn)品詳情 |
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| Product Name | AAL-993 |
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| Description | Purity >95%. AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively. It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor Beta, and EGF receptor (IC50 s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases. AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice. It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 μM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-benzamide, VEGFR Tyrosine Kinase Inhibitor VI, ZK 260253 |
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| Gene, Accession, CAS # | CAS: 269390-77-4 |
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| Catalog # | LS-H6367 |
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| Price | |
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| Order / More Info | AAL-993 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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