| 產(chǎn)品詳情 |
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| Antigenic Specificity | ADAR1 |
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| Clone | 15.8.6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 25 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC, KO/KD-Western Blot (WB), IHC-P |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-ADAR1. Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine in double-stranded RNAs (dsRNAs). The translation machinery reads inosine as guanosine, leading to recoding of a relatively small number of neurotransmitter and ion channel genes and diversification of their functions. Three ADAR gene family members (ADAR1-3) are known in vertebrates. Members of the ADAR gene family share common structural features, such as the presence of multiple dsRNA binding domains (dsRBDs) and a separate deaminase domain. Three repeats of dsRBD are present in ADAR1, while only two repeats are found in ADAR2 and ADAR. ADAR1 increases the rate of pre-microRNA cleavage by Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes. ADAR1 differentiates its functions in RNA editing and RNAi by formation of either ADAR1/ADAR1 homodimer or Dicer/ADAR1 heterodimer complexes. The deficiency of ADAR1 embryonically lethal due to overall apoptosis. |
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| Immunogen | dsRNA binding domain |
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| Other Names | DRADA, Double-stranded RNA-specific adenosine deaminase, p136, IFI-4 |
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| Gene, Accession # | Gene ID: 103 |
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| Catalog # | 685901 |
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| Price | |
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| Order / More Info | ADAR1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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