| 產(chǎn)品詳情 |
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| Antigenic Specificity | CD14 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, k |
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| Format | purified |
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| Size | 100ul, 50ul |
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| Concentration | n/a |
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| Applications | ELISA, WB, Flow cytometry |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48kDa) or is directly secreted from intracellular vesicles (56kDa).The x-ray crystal structure of human CD14 reveals a monomeric, bent solenoid structure containing a hydrophobic amino-terminal pocket. CD14 was the first described pattern recognition receptor. CD14 acts as a co-receptor (along with the Toll-like receptor TLR4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns such as lipoteichoic acid. |
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| Immunogen | Recombinant human CD14 (20-349aa) purified from E.coli. |
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| Other Names | monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein |
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| Gene, Accession # | NP 001167576 |
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| Catalog # | ATGA0339 |
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| Price | |
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| Order / More Info | CD14 Antibody from ATGen |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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