| 產(chǎn)品詳情 |
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| Antigenic Specificity | Caspase-9 |
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| Clone | 96-2-22 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | IP, Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Caspase-9. Recognizes 46 kD pro-caspase-9 and 34 kD cleaved caspase-9. Caspase 9 (also known as ICE-like apoptotic protease 6 (ICE-LAP6), apoptotic protease Mch-6, and apoptotic protease activating factor 3 (Apaf-3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. Pro-Caspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, Bcl-XL, c-IAP1, c-IAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf-1/cytochrome c complex, and following cleavage by Apaf-1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 interacts with BIRC7 and has been shown to cleave PARP and vimentin. The 96-2-22 monoclonal antibody has been shown to be useful for Western blotting of human caspase 9 (46 kD pro-caspase 9 as well as the 34 kD cleaved caspase 9). |
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| Immunogen | N-terminal fragment of human caspase-9 |
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| Other Names | Caspase-9 precursor, Casp9, ICE-like apoptotic protease 6 (ICE-LAP6), Apoptotic protease Mch-6, Apoptotic protease activating factor 3 (Apaf-3) |
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| Gene, Accession # | Gene ID: 842 |
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| Catalog # | 621902 |
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| Price | |
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| Order / More Info | Caspase-9 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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