| 產品詳情 |
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| Product Name | GDC 0879 |
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| Description | Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable. Purity 98%. MW (observed): 334.37 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime |
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| Gene, Accession, CAS # | CAS: 905281-76-7 |
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| Catalog # | 4453/50 |
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| Price | |
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| Order / More Info | GDC 0879 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 產品資料 |
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