| 產(chǎn)品詳情 |
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| Product Name | AT-13148 |
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| Description | AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predominant effect on apoptosis genes. MW: 313.78. Purity ≥98% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol |
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| Gene, Accession, CAS # | CAS: 1056901-62-2 |
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| Catalog # | B1144-5 |
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| Order / More Info | AT-13148 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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