| 產品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | ASK1 |
|---|
| Clone | 2E4 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 μL |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry: 1/200 - 1/400, Immunocytochemistry: 1:200-1:1000, Immunofluorescence: 1/200 - 1/1000, Immunohistochemistry: 1/200 - 1/1000, Western Blot: 1/500 - 1/2000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | ASK1 Monoclonal Antibody (2E4). Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. A |
|---|
| Immunogen | n/a |
|---|
| Other Names | RP3-325F22.4, ASK1, MAPKKK5, MEKK5, ASK-1; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1 |
|---|
| Gene, Accession # | Entrez: 4217; Uniprot: Q99683 |
|---|
| Catalog # | MA5-15861 |
|---|
| Price | |
|---|
| Order / More Info | ASK1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 27364558 |
|---|
| 產品資料 |
|
|