| 產(chǎn)品詳情 |
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| Antigenic Specificity | DOK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 500 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DOK1 Polyclonal Antibody. DOK-1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK-1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK-1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK-1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. |
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| Immunogen | n/a |
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| Other Names | P62DOK, Downstream of tyrosine kinase 1, docking protein 1, docking protein 1 downstream of tyrosine kinase 1, p62dok, pp62 |
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| Gene, Accession # | Entrez: 1796; Uniprot: Q99704 |
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| Catalog # | PA5-32384 |
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| Price | |
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| Order / More Info | DOK1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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