| 產(chǎn)品詳情 |
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| Antigenic Specificity | Phospho-DOK1 (Tyr362) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 1:50-1:200, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-DOK1 (Tyr362) Polyclonal Antibody. Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of docking proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. |
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| Immunogen | n/a |
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| Other Names | Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK1, Downstream of tyrosine kinase 1, p62(dok), P62DOK, pp62 |
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| Gene, Accession # | Entrez: 13448, 1796, 312477; Uniprot: P97465, Q4QQV2, Q99704 |
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| Catalog # | PA5-36845 |
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| Price | |
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| Order / More Info | Phospho-DOK1 (Tyr362) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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